Inspiration often comes from the most unexpected places.

Perseverance is key in the face of adversity.

Encourage experimentation within your team.

Clarity in communication is vital.

Blogging got the concept of personal publishing, but it didn’t really take advantage of the network.

Quality over quantity should be the mantra.

Networking is about building genuine relationships.

The journey of entrepreneurship is as important as the destination.

Creativity thrives in open environments.

Traditional news is often full of mistakes, but I think that people are getting more sophisticated in knowing what to trust and what not to trust.

Sustainability in business is crucial.

Empower your team to take ownership.

Data-driven decisions lead to better outcomes.

‘Vanity pages,’ is somewhat of a derogatory term; personal pages are still the heart of blogging, but now there are more topic-oriented blogs. It’s really about personal expression, and that’s just gotten bigger and broader.

I think Twitter will be a fundamental part of how people interact with their government.

Adaptation is a critical skill.

Scalability is key to success.

Keep your focus on solving real problems.

Failures teach us invaluable lessons.

I subscribe to about 200 blogs. I look for insights and good writing, and I look to get smarter.

The best entrepreneurs are great storytellers.

People are fans of Dunkin’ Donuts. They have a relationship with the company, they go there every day. Dunkin’ Donuts is using Twitter to communicate with those people. There are people who are finding value in that. There’s thousands of people, I don’t know how many thousands now, following Dunkin’ Donuts.

Feedback is a gift; embrace it.

Trust the process and the people involved.

A key element of Web blogs is the community element. Most blogs are not self-contained; they are highly dependent on linking to each other.

Build for the future, not just the present.

Start small, think big.

After high school, I enrolled at the University of Nebraska at Lincoln, but I stayed only a year and a half. I felt college was a waste of time; I wanted to start working.

Your team is your greatest asset.

While GeoCities isn’t cool, it isn’t a bad thing. It did a great thing – enabled great people to instantly publish to the Web.

Create value before seeking profit.

I think there’s few cases in history where the C.E.O. steps down and is also the founder and reports to someone and that works.

I suspect there’s a lot of validity to the premise that big companies aren’t going to attract entrepreneurial talent.

Embrace change and be willing to pivot.

I mistrust anyone… if they’re saying, ‘Well, that market wants this,’ and you’re not part of that market.

Good design is about how it works, not just how it looks.

News in general doesn’t matter most of the time, and most people would be far better off if they spent their time consuming less news and more ideas that have more lasting import.

Every time you start a company – and I’ve started five or six – you have the opportunity to screw up in whole new ways.

When I meet with the founders of a new company, my advice is almost always, ‘Do fewer things.’ It’s true of partnerships, marketing opportunities, anything that’s taking up your time. The vast majority of things are distractions, and very few really matter to your success.

I used to tweet about the most mundane things – like ‘I just bought a soya latte’ – but now I try and make it a bit more interesting.

The power of technology lies in its ability to connect people.

User experience is paramount.

Marketing, when done well, is about story telling.

Our problem wasn’t that it blew up and was impossible to scale, but there were some bad choices made. One of the biggest lessons time after time was to focus. Do fewer things.

Twitter was designed to be this system that you just scan for information that’s important or useful to you and then walk away, and if you wanna take a break you take a break.

Innovation comes from collaboration and openness.

Assume the best but hire paranoid people.

‘What is Twitter?’ has always been a tough question to answer.

The vast majority of things are distractions, and very few really matter to your success.

Most of the great businesses of our time have experimented. Like Google.

Listen to your users; they are your best source of feedback.

Great companies are built on great culture.

Twitter is about sharing what you’re thinking.

When you’re obsessing about one thing, you can reach insights about how to solve hard problems. If you have too many things to think about, you’ll get to the superficial solution, not the brilliant one.

Twitter isn’t a social network, it’s an information network.

Simplicity is key in building great products.

Don’t worry about failure; you only have to be right once.

User experience is everything. It always has been, but it’s undervalued and underinvested in. If you don’t know user-centered design, study it. Hire people who know it. Obsess over it. Live and breathe it. Get your whole company on board.

Take care of yourself: When you don’t sleep, eat crap, don’t exercise, and are living off adrenaline for too long, your performance suffers. Your decisions suffer. Your company suffers. Love those close to you: Failure of your company is not failure in life. Failure in your relationship is.

I’m not a big-company guy. I need freedom and control.

The best ideas come from being able to take risks.

Take a human desire, preferably one that has been around for a really long time Identify that desire and use modern technology to take out steps.

The things that keep nagging at you are the ones worth exploring.

Every major communication tool on the Internet has spam and abuse problems. All email services, blogging services and social networks have to dedicate a significant amount of resources and time to fighting abuse and protecting their users.

My life has been a series of well-orchestrated accidents; I’ve always suffered from hallucinogenic optimism.

You have to be a little bit crazy to start a company.

Change the world. Build a business. Have fun.

I was broke for more than 10 years. I remember staying up all night one night at my first company and looking in couch cushions the next morning for some change to buy coffee.

Hard things are valuable; easy things are not so valuable. Reaching the mountaintop is rewarding because it is hard. If it was easy, everybody would do it.

I like to think of the world as a sort of a casino, except the house doesn’t have the advantage. If you’re smart, you have an advantage. It behooves you to place a lot of bets.